Mary Lou Stapleton 80 of Clay City passed away Tuesday, April 12, 2022 at the Clark Regional Medical Center. She was born January 25, 1942 in Jackson to Arthur and Mandy Napier. She was a member of the Harvest Time Assembly of God and was a homemaker. She is survived by a son Donnie Stapleton (Tonya), two daughters Ruby Means (Elihue), Patricia Wilburn (Don), eight grandchildren, ten great grandchildren, a brother William Napier (Norma) and two sisters Opal Buckland and Lillie Taulbee (Frank). She was preceded in death by her parents, her husband Clyde Stapleton, a son Randy Stapleton, a daughter Valerie Stapleton, a grandchild Michael Paul Means, a brother Elmer Napier and his wife Mary Napier and a sister Juanita Campbel. Visitation will be Friday from 11 AM till time of the service. Funeral services will be held 1 PM Friday, April 15, 2022 at the Grayson Funeral Home Chapel in Clay City with Bro. Tony Story officiating. Burial will be in the Napier Cemetery in Clay City. Grayson Funeral Home is in charge of services.